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 MEDICAL

There are various drugs for the treatment of different diseases.

The Liver diseases have been listed down in alphabetical order. Click on the alphabet to read more about the diseases.

 
A
B
 
Porphyria Primary Biliary Cirrhosis PBC
Contraindications and side effects of medications Primary Sclerosing Cholangitis PSC
 

Porphyria

Treatment Indication Dose
Sunscreen Sunscreen and protective clothing can minimize exposure to Ultraviolet light.

 

Beta-carotene This vitamin can neutralize porphyrins (harmful products created by exposure to UV light). Indicated for patients in whom sunscreen and protective clothing is not sufficient to control symptoms. 120-180 mg by mouth once daily.
Activated charcoal Absorbs porphyrins and hastens their removal in the stool. Indicated for patients in whom sunscreen and protective clothing is not sufficient to control symptoms. 500-520 mg by mouth after meals.
Cholestyramine Absorbs porphyrins and hastens their removal in the stool. Indicated for patients in whom sunscreen and protective clothing is not sufficient to control symptoms. Optimal dose undefined
Chloroquine Used in porphyria cutanea tarda to absorb porphyrins and hasten removal in urine. It is an important therapy when phlebotomy (removal of blood) is not possible because of other medical conditions. 125 mg by mouth twice weekly.
Hemin This intravenous heme preparation is recommended to curtail an acute attack. 3 to 4 mg per kg of body weight once daily by intravenous administration given over a period of 10 to 15 minutes for 4-14 days.
Cimetidine Used if standard therapies have failed to curtail an acute attack. This medication is much cheaper than hemin. 800 mg by mouth once daily.
   

Contraindications and side-effects of medications

Medication Reasons not to take this medicine Side-effects
Albendazole If you have an allergy to albendazole or any other part of this medicine.

Worsening laboratory tests of liver function

Hair loss.

Belly pain.

Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

Activated charcoal Do not take this medication if your stomach or intestine is blocked or perforated.

Not recommended in children less than 1 year old.
Vomiting.

Diarrhea.

Constipation

Swelling of abdomen.

Abnormalities in levels of blood minerals.
Beta-Carotene If you have an allergy to beta-carotene or any other part of this medicine.

If you have severe kidney disease.
Yellowing of palms, hands, or soles of feet

Bruising
Cimetidine If you have an allergy to cimetidine or any other part of this medicine. Headache.

Diarrhea.

Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.
Chloroquine If you have an allergy to chloroquine phosphate or any other part of this medicine.

If you have any changes in vision due to chloroquine.
Anemia.

Belly pain.

Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

Eye damage can rarely occur.
Cholestyramine If you have an allergy to cholestyramine or any other part of this medicine.If you have a blockage in your intestine. Headache.

Abdominal bloating.

Diarrhea.

Gallstones.

Pancreatic irritation.
Hemin If you have an allergy to hemin or any other part of this medicine. Mild fever.

Inflammation at injection site.

Increase in white blood cell levels.
Mebendazole If you have an allergy to mebendazole or any other part of this medicine. Swelling of hands, feet, and face.

Fever.

Headache, dizziness.

Convulsions (seizure).

Rash.

Itching.

Hair loss.

Belly pain.

Diarrhea.

Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
Ribavarin If you have an allergy to ribavirin or any other part of this medicine.

If you have any of the following conditions: Autoimmune hepatitis, poor kidney function, sickle cell anemia, or thalassemia major.

If you are taking ribavirin alone for treatment of hepatitis C infection.

If you are of childbearing age, but are not using two forms of birth control or if you are planning to become pregnant during your treatment or within 6 months after treatment has ended.

If you are a male patient with a sexual partner who is pregnant or plans on becoming pregnant at any time while you are being treated or within 6 months after your treatment has ended.

If you are pregnant or may be pregnant.

If you are breast-feeding.
Feeling lightheaded, sleepy, having blurred vision, or a change in thinking clearly. Avoid driving, doing other tasks or activities that require you to be alert or have clear vision until you see how this medicine affects you.

Anemia.

Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.Not hungry.
   

Primary Biliary Cirrhosis (PBC)

Treatment Indication Dose
Pancrelipase Helps improve foul-smelling, fatty diarrhea caused by lack of chemicals necessary to digest food.

Adjust dose to correct symptoms. Maximum dose: 2500 units of lipase per kg of body weight per meal by mouth (10,000 units of lipase per kg per day): 4000-48,000 units of lipase with meals and with snacks.

Levothyroxine Used in the 20% of PBC patients who also develop hypothyroidism.  
Propanolol Used to prevent gastrointestinal bleeding in patients with anemia that cannot be corrected with iron replacement. Lowest dose that lowers resting pulse by 25%.
Ursodeoxycholic acid Reduces the concentration of bile acids and has been shown to delay progression to end-stage liver disease and improve survival. 13-15 mg per kg of body weight by mouth once daily.
   

The studies are less conclusive for Modafinil (for fatigue) and Methotrexate, Colchicine (for treating underlying cause) and so I have not included these drugs.

Primary Sclerosing Cholangitis

None of the therapies, including ursodeoxycholic acid have been conclusively shown benefit symptoms or survival in this condition.
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